簡(jiǎn)要描述:NPRL2 Polyclonal Antibody宿主: Polyclonal, Rabbit,IgG反應性: Human;Mouse;Rat應用: WB;ELISA
產(chǎn)品型號: YP-Ab-00560
所屬分類(lèi):多克隆抗體
更新時(shí)間:2023-10-19
抗體,也叫免疫球蛋白(Ig),是一種能特異性結合抗原的糖蛋白,而抗原是在易感染動(dòng)物體內引發(fā)抗體產(chǎn)生的物質(zhì)。在體內,抗體是由于外源性分子的侵襲而產(chǎn)生的??贵w以一個(gè)或者多個(gè)Y字形單體存在,每個(gè)Y字形單體由4條多肽鏈組成,包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據它們的分子量大小來(lái)命名的。Y字形結構的頂端是可變區,為抗原結合部位。任何一個(gè)抗體的輕鏈都可以分為κ或λ型(基于小分子多肽結構上的差異),每一個(gè)抗體的重鏈則決定了它的類(lèi)或型。
function:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.,similarity:Belongs to the NPR2 family.,subunit:Interacts with PDPK1.,tissue specificity:Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested
備注:圖片僅供參考。僅供科研,不可用于臨床。