簡(jiǎn)要描述:Ku80 mouse mAb宿主: Monoclonal, Mouse反應性: Human;Monkey應用: WB;IF;IP
產(chǎn)品型號: YP-Ab-00102
所屬分類(lèi):單克隆抗體
更新時(shí)間:2023-10-22
抗體,也叫免疫球蛋白(Ig),是一種能特異性結合抗原的糖蛋白,而抗原是在易感染動(dòng)物體內引發(fā)抗體產(chǎn)生的物質(zhì)。在體內,抗體是由于外源性分子的侵襲而產(chǎn)生的??贵w以一個(gè)或者多個(gè)Y字形單體存在,每個(gè)Y字形單體由4條多肽鏈組成,包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據它們的分子量大小來(lái)命名的。Y字形結構的頂端是可變區,為抗原結合部位。任何一個(gè)抗體的輕鏈都可以分為κ或λ型(基于小分子多肽結構上的差異),每一個(gè)抗體的重鏈則決定了它的類(lèi)或型。
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
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